Impact of RNA editing or mutations on post-transcriptional regulation in cancer

The primary sequence of an mRNA encodes not only the information that codes for its protein product, but also regulatory information that influences its splicing, localization, translation, stability and modifications. This sequence information is read by various RBPs and non-coding RNAs that affect the post-transcriptional regulation of the mRNA. As such, changes to the mRNA sequence can potentially affect multiple aspects of its post-transcriptional regulation. We are interested in how sequence changes that arise from RNA editing by base editors like ADAR, or through mutations, influence post-transcriptional regulation in cancer.

More details to come…